Wednesday 4 July 2012

Why do we suffer from polycystic kidney disease?


Polycystic kidney disease will have a huge impact to the health and life of the patients, many patients with polycystic kidney want is not suffering from polycystic kidney disease like. So why do we suffer from polycystic kidney disease?
Why do we suffer from polycystic kidney disease?
Renal cyst is due to the formation of the cyst epithelial cells of renal tubular epithelial cell variation, and abnormal secretion of cystic fluid, making the formation of cysts and cyst fluid secretion and exclude imbalance. Cyst age increases gradually increasing cyst epithelial cells secrete cyst fluid with no discharge channels, the cyst gradually increasing, cyst rupture will result in acute abdominal infection, while the long-standing oppression of the renal parenchyma will inevitably lead to renal damage, Therefore, treatment for cysts, can not simply go to reduce the cyst, the key is to control the cysts to reduce the cyst on the basis of increased again, to prevent recurrence. Than 3cm cyst can be a positive program of traditional Chinese medicine taken by the infiltration of the kidney area of ​​the skin directly to the cyst, an expansion of the wall of blood vessels, away the cyst fluid, in order to shrink the cyst, is against the wall in a the activity of the epithelial cells, inactivated, it no longer secrete the cyst fluid, and thus control the growth of cysts, for therapeutic purposes.
Adult polycystic kidney disease occurs mainly in adults over the age of 30-50, and adult polycystic kidney disease is more common in clinical practice, the development of renal failure in autosomal dominant polycystic kidney disease late.
Polycystic kidney disease, according to their genetic characteristics, divided into adult polycystic kidney disease and infantile polycystic kidney disease (also known as the two types of autosomal recessive inheritance).
Patients with adult polycystic kidney disease manifests itself in bilateral renal enlargement, cortex, medulla multiple fluid cyst formation and increasing secondary to impaired renal function. Can affect multiple systems, such as the digestive system, cardiovascular system, central nervous system, reproductive system, the formation of liver cysts, splenic cyst, aneurysm, heart valve abnormalities. However, according to the latest research shows that the fetus, including any period can be onset.
Polycystic kidney disease is caused by?
Cyst genetically modified tubular epithelial cells and the wall of cell metabolism, so that:
① cyst gene tubule cells, Na-K-ATP enzyme, so the increase in the amount of fluid within the tubule, and the proliferation of wall cells to secrete liquid;
② small tubular epithelial cells continued proliferation, the formation of polyp-like lesions caused by tubular obstruction. Obstruction in front of the tube, fluid retention, expansion into the cyst. In addition, polyp-like substance formed by the proliferation in the cyst neck can be caused by semi-obstruction, so that the liquid is not easy out, then expand the cyst;
Stimulate cyst gene ③ infection and toxin in the small tube, change the tubule cell metabolism, or even directly cause epithelial cell necrosis, and necrotic cell shedding may also cause obstruction, and necrosis after regeneration also promote cell proliferation.
The ④ tubule epithelial cells and wall cells to produce a series of biologically active substances to promote the secretion of the cyst fluid;
The ⑤ abnormal extracellular matrix, and changes in basement membrane and wall conditions, the development of cyst formation;

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