Thursday 5 July 2012

How to treat Leg edema with diabetic kidney disease


Patients with diabetic nephropathy are common symptoms of localized edema, which is due to impaired renal system, resulting in the body of water and toxins can not be excluded from the body, caused by the retention. Of edema and proteinuria plus sign is necessary and timely treatment, timely treatment will result in the lesions of various organs of the body functions, resulting in edema and proteinuria is necessary and timely medical treatment.
Diabetic nephropathy is the original or secondary cause of along with the immune regulatory dysfunction caused by elevated blood glucose, a series of pathological changes of intrinsic glomerular cells, a large number of immune complexes in the pathogenesis of deposition in the kidneys leading to glomerular basement membrane thickening, luminal narrowing, blood vessels, microcirculation, leading to renal ischemia and hypoxia, the intrinsic cells of the kidney damage can not stop the protein leak. In fact, the abnormal protein and the amount of urine is not only a disease indicators, but as an independent factor involved in the process of kidney disease. The study also found that the level of a variety of nephrotic proteinuria and chronic renal failure is closely related to the rate of progress, enables the protein to reduce the therapeutic interventions are beneficial to slow down the progression of kidney disease.
Protein loss of the formation of excessive hypoproteinemia, the loss of a protein from the glomerular capillaries, resulting in plasma colloid osmotic pressure (plasma colloid is a plasma protein), and the important role of the plasma colloid is to regulate the blood vessels inside and outside the water exchange, it appears that the osmotic pressure will lead to water retention in the interstitial to stay, cause edema. The same time, hypoproteinemia can cause the effective hypovolemia secondary aldosterone and antidiuretic hormone secretion, increased tubular reabsorption of water, sodium increases, causing swelling.
Symptomatic treatment for the treatment of diabetic nephropathy edema following methods: 1, in patients with edema with diuretics, spironolactone and thiazide drugs available is used in conjunction. 2, appears in patients with heart failure, edema can be applied to digitalis therapy. Sodium 3 patients with severe refractory edema can be used diuretic furosemide. 4, severe hypoproteinemia and edema in patients with intravenous albumin and essential amino acids. 5 patients with severe anemia, edema may be a small amount of blood transfusion.
But in the end, in order to radically improved edema and diabetic nephropathy caused by other complications, the most important treatment is to step up to the kidneys. To confirm the diagnosis of the type of kidney immune and inflammatory response and immune complex deposition in the kidney site targeted drug therapy. To timely protection of residual renal function treatment, we can achieve the purpose of disease control.

1 comment:

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